What is Genetic ALS?

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Video - Information

Client's Name


Country / Region

United States

Amyotrophic Lateral Sclerosis (ALS) is a rare and poorly understood disease. It was once thought that ALS only had a genetic

component in people with a family history of the disease, but we now know that even so-called

“sporadic” ALS may be caused by a genetic mutation.

This video details the worldwide prevalence of ALS, examines the cultural impact of the fight

against the disease, and untangles the intricacies of what, exactly, we mean when we say,

“genetic ALS”—all in just over three minutes.

Beginning with a concise overview of the global prevalence of ALS, the video quickly and

elegantly transitions to a sequence in which one of the figures on screen pours ice water over

his head—a telegraphic reminder of the massive affect this relatively rare disease has had on

the lives of people worldwide, as evidenced by the stories and images shared during the Ice

Bucket Challenge in 2015. From there, visuals and voiceover move together through the genes

associated with ALS, how mutations in those genes lead to the symptoms of the disease,

and—crucially—the importance and availability of genetic testing to determine who may be

eligible for treatment.

By ending on this note and depicting the countries around the world where genetic testing and

research is taking place, we remind viewers that—for the first time—we are finding a clear way

forward in the fight against genetic ALS.


Broth Founding Partner and Creative Guy - Creative oversight
Ted Kossakowski
Broth Founding partner and Creative Guy - Copy oversight
Douglas H Tischler
Broth Founding Partner, Science & Strategy - Medical oversight
Elizabeth Yi, PhD
Group Account Lead, Broth
Katherine Sherwood
Global Account Lead, Broth
Crystal Clark
Creative Director, Art, Broth
Meredith Kennedy
Group Writing Lead, Broth
Max Berry
Producer, Polyester Studio
Alyssa Molfetta
Head of Production, HOBO Audio
John Mackey
Editorial Director, Broth
Pauline Orendain
Scientific Director, Broth
Jenn Lee, PhD
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